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Endocrine Abstracts

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ea0099p12 | Adrenal and Cardiovascular Endocrinology | ECE2024

How to assess adrenal function during low dose prednisolone treatment – impact of a 1- vs 2-day prednisolone pause before the ACTH test: Results from the Double Edge-Rescue Study

Willemoes Borresen Stina , Hansen SimonBoggild , Al-Jorani Hajir , Bislev LiseSofie , Boesen VictorBrun , Christensen LouiseLehmann , Feldt-Rasmussen Ulla , Dreyer AnjaFenger , Glintborg Dorte , Jensen RichardChristian , Jorgensen NannaThurmann , Lund MarieLouise , Okutan Sema , Stankovic Jelena , Tei Randi , Hetland MereteLund , Locht Henning , Hauge Ellen , Keller Kresten , Just SorenAndreas , Voss Anne , Sorensen Henrik Toft , Stewart Paul M. , Jorgensen JensOtto , Andersen Marianne , Klose Marianne

Background: Correctly identifying glucocorticoid-induced adrenal insufficiency in patients tapering prednisolone treatment to ≤5 mg daily is crucial. Pausing prednisolone before an ACTH-test is standard, yet the optimal pause duration is uncertain.Aim: To determine the outcome of an ACTH-test after 1 vs 2 days’ prednisolone pause before the test.Methods: Baseline data from an ongoing randomised clinical trial (EudraCT:20...
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ea0099p228 | Adrenal and Cardiovascular Endocrinology | ECE2024

Impact of glucocorticoid-induced adrenal insufficiency on health-related quality of life in patients receiving long-term low dose prednisolone treatment: Results from the double edge-rescue trial

Lund Marie Louise , Al-Jorani Hajir , Stankovic Jelena , Bislev Lise Sofie , Bjorner Jakob Bue , Boesen Victor Brun , Christensen Louise Lehmann , Feldt-Rasmussen Ulla , Dreyer Anja Fenger , Glintborg Dorte , Hansen Annette , Hansen Simon Boggild , Jensen Richard Christian , Jorgensen Nanna Thurmann , Klose Marianne , Locht Henning , Tei Randi , Watt Torquil , Stewart Paul M. , Sorensen Henrik Toft , Jorgensen Jens Otto , Andersen Marianne , Borresen Stina Willemoes

Objectives: The clinical impact of glucocorticoid-induced adrenal insufficiency in patients on low-dose prednisolone is unclear. We investigated the influence of adrenal function on health-related quality of life (HRQoL) in patients tapering prednisolone.Method: Baseline data from an ongoing prospective randomised clinical trial including 278 patients with polymyalgia rheumatica/giant cell arteritis treated with prednisolone for ≥12 weeks, current ...
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ea0099rc11.5 | Rapid Communications 11: Adrenal and Cardiovascular Endocrinology | Part II | ECE2024

Assessment of adrenal function after prednisolone treatment in patients with polymyalgia rheumatica and/or giant cell arteritis – Data from the double edge-replace study

Boggild Hansen Simon , Fenger Dreyer Anja , Jorgensen Nanna Thurmann , Al-Jorani Hajir , Sofie Bislev Lise , Boesen Victor Brun , Borresen Stina Willemoes , Christensen Louise Lehmann , Glintborg Dorte , Hamge Ellen , Hetland Merete Lund , Jensen Richard Christian , Just Soren Andreas , Keller Kresten , Klose Marianne , Lamgesen Kristina , Lund Marie Louise , Stankovic Jelena , Stewart Paul M , Sorensen Henrik Toft , Tei Randi , Voss Anne , Feldt-Rasmussen Ulla , Jorgensen Jens Otto , Andersen Marianne

Introduction: Pharmacological glucocorticoid (GC) treatment may cause iatrogenic adrenal insufficiency (GIA), although the prevalence and clinical implications are debated. With 3% of the Danish population redeeming prescriptions of systemic GC annually, the number of patients at risk is potentially extensive. Taken together, there is an unmet need for a prospective and unbiased assessment of the GIA prevalence.Materials and Methods: The data for this re...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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